| 9/28/2010 9:47 | ||||||
| Week 3 | ||||||
| Away | Score | Home | Score | Odds | Winner | |
| TEN | 29 | NYG | 10 | -3 | TEN | |
| CIN | 20 | CAR | 7 | 3 | CIN | |
| DAL | 27 | HOU | 13 | -3 | DAL | |
| SF | 10 | KC | 31 | 2.5 | KC | |
| PIT | 38 | TB | 13 | 3 | PIT | |
| BUF | 30 | NE | 38 | -14 | BUF | |
| CLE | 17 | BAL | 24 | -10.5 | CLE | |
| DET | 10 | MIN | 24 | -11 | MIN | |
| ATL | 27 | NO | 24 | -4 | ATL | |
| WAS | 16 | STL | 30 | 3.5 | STL | |
| PHI | 28 | JAC | 3 | 3 | PHI | |
| IND | 27 | DEN | 13 | 5.5 | IND | |
| OAK | 23 | ARI | 24 | -4.5 | OAK | |
| SD | 20 | SEA | 27 | 5.5 | SEA | |
| NYJ | 31 | MIA | 23 | -2.5 | NYJ | |
| GB | 17 | CHI | 20 | 3 | CHI | |
| Odds indicate HOME team's | ||||||
| (dis)advantage. Byes listed below. | ||||||