| 9/21/2010 11:00 | ||||||
| Week 2 | ||||||
| Away | Score | Home | Score | Odds | Winner | |
| BUF | 7 | GB | 34 | -13 | GB | |
| BAL | 10 | CIN | 15 | 2 | CIN | |
| PIT | 19 | TEN | 11 | -5 | PIT | |
| CHI | 27 | DAL | 20 | -8.5 | CHI | |
| PHI | 35 | DET | 32 | 4.5 | DET | |
| TB | 20 | CAR | 7 | No Line | ||
| ARI | 7 | ATL | 41 | -6.5 | ATL | |
| KC | 16 | CLE | 14 | -1.5 | KC | |
| MIA | 14 | MIN | 10 | -5.5 | MIA | |
| SEA | 14 | DEN | 31 | -3.5 | DEN | |
| STL | 14 | OAK | 16 | -3.5 | STL | |
| HOU | 30 | WAS | 27 | 3 | PUSH | |
| JAC | 13 | SD | 38 | -7.5 | SD | |
| NE | 14 | NYJ | 28 | 1.5 | NYJ | |
| NYG | 14 | IND | 38 | -5.5 | IND | |
| NO | 25 | SF | 22 | 5.5 | SF | |
| Odds indicate HOME team's | ||||||
| (dis)advantage. Byes listed below. | ||||||