| 9/21/2010 11:09 | ||||||
| Week 1 | ||||||
| Away | Score | Home | Score | Odds | Winner | |
| MIN | 9 | NO | 14 | 0 | NO | |
| ATL | 9 | PIT | 15 | 1.5 | PIT | |
| CLE | 14 | TB | 17 | -3 | PUSH | |
| IND | 24 | HOU | 34 | 2 | HOU | |
| DEN | 17 | JAC | 24 | -3 | JAC | |
| CIN | 24 | NE | 38 | -5.5 | NE | |
| MIA | 15 | BUF | 10 | 3 | MIA | |
| OAK | 13 | TEN | 38 | -6 | TEN | |
| DET | 14 | CHI | 19 | -6.5 | DET | |
| CAR | 18 | NYG | 31 | -6.5 | NYG | |
| ARI | 17 | STL | 13 | 3.5 | ARI | |
| GB | 27 | PHI | 20 | 3 | GB | |
| SF | 6 | SEA | 31 | 3 | SEA | |
| DAL | 7 | WAS | 13 | 3.5 | WAS | |
| BAL | 10 | NYJ | 9 | -2.5 | BAL | |
| SD | 14 | KC | 21 | 4 | KC | |
| Odds indicate HOME team's | ||||||
| (dis)advantage. Byes listed below. | ||||||