| 12/3/2010 9:58 | ||||||
| Week 12 | ||||||
| Away | Score | Home | Score | Odds | Winner | |
| NE | 45 | DET | 24 | 6.5 | NE | |
| NO | 30 | DAL | 27 | 4 | DAL | |
| CIN | 10 | NYJ | 26 | -9 | NYJ | |
| JAC | 20 | NYG | 24 | -7 | JAC | |
| PIT | 19 | BUF | 16 | 6.5 | BUF | |
| TEN | 0 | HOU | 20 | No Line | ||
| MIN | 17 | WAS | 13 | -2 | MIN | |
| PHI | 26 | CHI | 31 | 3.5 | CHI | |
| GB | 17 | ATL | 20 | -2 | ATL | |
| TB | 10 | BAL | 17 | -7.5 | TB | |
| CAR | 23 | CLE | 24 | -10.5 | CAR | |
| KC | 42 | SEA | 24 | 1.5 | KC | |
| MIA | 33 | OAK | 17 | No Line | ||
| STL | 36 | DEN | 33 | -4 | STL | |
| SD | 36 | IND | 14 | -3 | SD | |
| SF | 27 | ARI | 6 | 1 | SF | |
| Odds indicate HOME team's | ||||||
| (dis)advantage. Byes listed below. | ||||||