| 9/22/2009 9:23 | ||||||
| Week 2 | ||||||
| Away | Score | Home | Score | Odds | Winner | |
| HOU | 34 | TEN | 31 | -6.5 | HOU | |
| CAR | 20 | ATL | 28 | -6.5 | ATL | |
| MIN | 27 | DET | 13 | 10 | MIN | |
| ARI | 31 | JAC | 17 | -3 | ARI | |
| OAK | 13 | KC | 10 | -3 | OAK | |
| NO | 48 | PHI | 22 | 0 | NO | |
| CIN | 31 | GB | 24 | -9 | CIN | |
| STL | 7 | WAS | 9 | -10 | STL | |
| NE | 9 | NYJ | 16 | 3.5 | NYJ | |
| TB | 20 | BUF | 33 | -5 | BUF | |
| SEA | 10 | SF | 23 | -1.5 | SF | |
| BAL | 31 | SD | 26 | -3 | BAL | |
| PIT | 14 | CHI | 17 | 3 | CHI | |
| CLE | 6 | DEN | 27 | -3 | DEN | |
| NYG | 33 | DAL | 31 | -3 | NYG | |
| IND | 27 | MIA | 23 | 3 | IND | |
| Odds indicate HOME team's | ||||||
| (dis)advantage. Byes listed below. | ||||||