| 9/21/2009 11:17 | ||||||
| Week 1 | ||||||
| Away | Score | Home | Score | Odds | Winner | |
| TEN | 10 | PIT | 13 | -6.5 | TEN | |
| JAC | 12 | IND | 14 | -7 | JAC | |
| DET | 27 | NO | 45 | -10.5 | NO | |
| PHI | 38 | CAR | 10 | -2.5 | PHI | |
| DAL | 34 | TB | 21 | 3 | DAL | |
| NYJ | 24 | HOU | 7 | -3.5 | NYJ | |
| KC | 24 | BAL | 38 | -7 | BAL | |
| DEN | 12 | CIN | 7 | 2.5 | DEN | |
| MIN | 34 | CLE | 20 | 3 | MIN | |
| MIA | 7 | ATL | 19 | -4 | ATL | |
| WAS | 17 | NYG | 23 | -6 | PUSH | |
| SF | 20 | ARI | 16 | -7 | SF | |
| STL | 0 | SEA | 28 | -7 | SEA | |
| CHI | 15 | GB | 21 | -3 | GB | |
| BUF | 24 | NE | 25 | -9.5 | BUF | |
| SD | 24 | OAK | 20 | 7 | OAK | |
| Odds indicate HOME team's | ||||||
| (dis)advantage. Byes listed below. | ||||||